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NeoSculpt
NeoSculpt Plus + Flex
Two-device platform for derma-fat regeneration and muscle restoration, made in Korea and supplied through Kaihan Therapeutics. Origin Made in KoreaPlus 1 to 2 MHz, 43 to 45°C, 30 mm depthFlex EMS 8 channel + ICT 4 channel View details
REJUMÉ
REJUMÉ Demon Skin Booster
Glyceollin-based skin booster for pigmentation and brightening, developed in Korea and supplied through Kaihan Therapeutics. Active Glyceollin (soy phytoalexin)Origin Made in KoreaOne set 5 boxes, 10 patient treatments View details
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NeoSculpt Plus + Flex
Two-device platform for derma-fat regeneration and muscle restoration, made in Korea and supplied through Kaihan Therapeutics.
- Origin
- Made in Korea
- Plus
- 1 to 2 MHz, 43 to 45°C, 30 mm depth
- Flex
- EMS 8 channel + ICT 4 channel
- Certification
- KFDA, US FDA 510(k) for Plus
NeoSculpt is a two-device energy-based platform developed and made in South Korea by a practicing dermatologist and supplied in Thailand through Kaihan Therapeutics. It is positioned around a new category called Derma-Fat Regeneration (DFR): rebuilding the derma-fat layer rather than only tightening it.
The Two Devices
| Device | Role | Specs |
|---|---|---|
| NeoSculpt Plus | Derma-Fat Regeneration (DFR) | 1 to 2 MHz, 43 to 45°C sustained, 30 mm depth. Reaches the derma-fat junction (Mendelson Layer 2), about 12× deeper than conventional monopolar RF (2.5 mm). |
| NeoSculpt Flex | Muscle layer restoration | EMS 8 channel + ICT 4 channel, face and body, about 600 cm² coverage, roughly 4× broader than emSculpt/CoolTone. |
Together, dermis, fat pad and muscle are addressed in one protocol: Plus rebuilds the foundation, Flex restores the muscle layer beneath it.
Certifications
- KFDA certified (both devices).
- US FDA 510(k) cleared (NeoSculpt Plus).
- Korea GMP manufactured.
- Patented Korean sustained sub-thermal monopolar RF technology.
How It Works
Conventional monopolar RF heats to 60 to 70°C, denaturing collagen to tighten tissue (coagulation, scar response). NeoSculpt Plus sustains 43 to 45°C, below the coagulation threshold, to trigger a regenerative cascade instead: apoptosis of aged adipocytes, CD-68+ macrophage clearance, fibroblast and ADSC reactivation, then new collagen and adipocyte regeneration. Published studies cite four published mechanistic pathways (thermal biology and HSP activation, p38 MAPK, TRPV1 activation, MSC/ADSC activation).
The dWAT (dermal white adipose tissue) regeneration cycle described in the published data runs in three stages over about 12 weeks: lipolysis (weeks 0 to 4), dedifferentiation (weeks 4 to 8), redifferentiation into new, healthy fat tissue (weeks 8 to 12+).
Clinical Evidence
- SNUBH study (n=20, 6-month prospective, IRB-approved, registered on ClinicalTrials.gov): significant improvement in jawline length, midface width and lower face width (all p<0.001); average GAIS 2.67; patient satisfaction 8.75/10; pain 3.25/10 with no anesthesia; no serious adverse events.
- Dong-A University Hospital study (n=27, 9-month prospective, independent second cohort): consistent results, same average GAIS and pain scores, effect maintained at 9 months.
- Porcine in-vivo histology (Koo D-W et al., In Vivo 2024): −25% adipocyte size, +2.5× dermal collagen content, confirmed by Perilipin/CD-68 immunohistochemistry.
Protocol
The standard combination (the “Neo & Wegovy Program”, in clinical use in Korea since 2024) is a 4-week cycle: NeoSculpt Plus ×1 + NeoSculpt Flex ×3. A Plus session is a quick in-office procedure (under 10 minutes, 6 to 12 shots, no anesthesia needed, pain typically mild).
- GLP-1 combination: for patients on weekly Wegovy or Mounjaro. GLP-1 drives systemic fat loss (including facial volume and muscle), Plus regenerates the derma-fat layer to prevent hollowing and sagging, Flex rebuilds the muscle GLP-1 takes away (about 25% of total weight loss can be muscle).
- Botox combination: for long-term toxin patients whose muscle layer has atrophied and whose face has started to sag. Botox continues managing the muscle as before, Plus rebuilds the derma-fat foundation underneath without altering the toxin protocol.
REJUMÉ Demon Skin Booster
Glyceollin-based skin booster for pigmentation and brightening, developed in Korea and supplied through Kaihan Therapeutics.
- Active
- Glyceollin (soy phytoalexin)
- Origin
- Made in Korea
- One set
- 5 boxes, 10 patient treatments
- Course
- 5 to 8 sessions
- Status
- Registered as cosmetic
REJUMÉ Demon Skin Booster is a Korean-made skin booster supplied in Thailand through Kaihan Therapeutics. Its active ingredient is glyceollin, a soy-derived phytoalexin studied for a brightening and anti-pigmentation mechanism. It targets pigmentation and brightness, a different niche from collagen-stimulating boosters.
What’s In a Set
1 set = 5 boxes. Each box contains a 3 ml main vial and a 6 ml booster vial. The two are mixed to 9 ml (the booster balances osmotic pressure, making injection comfortable), enough for up to 2 patients per box. 1 set = 10 patient treatments.
Protocol
- Delivery: injection (not MTS-only).
- Frequency: weekly or every 10 days.
- Course: 5 to 8 sessions.
- Mixed vial storage: refrigerated, use within 1 week.